Here are the most recent, relevant findings I can see about Interferon-inducible GTPase 5 (GBP5)—specifically new work published in late 2025 that expands its antiviral mechanism.
If you tell me whether you mean human GBP5 (gene GBP5) and whether you care most about COVID/SARS-CoV-2, HIV, or inflammasome/immune signaling (e.g., NLRP3), I can narrow this to the most relevant “latest news” threads and summarize them.
Interferon (IFN)-induced guanosine triphosphate hydrolysing enzymes (GTPases) have been identified as cornerstones of IFN-mediated cell-autonomous defence. Upon IFN stimulation, these GTPases are highly expressed in various host cells, where they ...
pmc.ncbi.nlm.nih.govViral infection induces production of type I interferons and expression of interferon-stimulated genes (ISGs) that play key roles in inhibiting viral infection. Here, we show that the ISG guanylate-binding protein 5 (GBP5) inhibits N-linked ...
pmc.ncbi.nlm.nih.govCell-autonomous immunity is essential for host organisms to defend themselves against invasive microbes. In vertebrates, both the adaptive and the innate branches of the immune system operate cell-autonomous defenses as key effector mechanisms that ...
pmc.ncbi.nlm.nih.gov