New research indicates that individuals with insomnia who take melatonin supplements for over a year face a higher risk of heart failure compared to those who do not use this common sleep aid. The study suggests a correlation between prolonged melatonin use and increased chances of being diagnosed with heart failure, needing hospitalization due to the condition, or dying from any cause.
The findings were presented at the American Heart Association’s Scientific Sessions 2025 in New Orleans but have not yet undergone peer review. Researchers emphasize that the study does not prove a direct cause-and-effect link between melatonin and heart failure risks.
“Melatonin supplements may not be as harmless as commonly assumed."
Researchers call for caution and additional research to better understand the cardiovascular safety of melatonin when used long term.
Prolonged melatonin use among people with insomnia may increase heart failure risk, underscoring the need for careful evaluation of its safety and regulation.