Long-Term Melatonin Use May Pose Heart Risks
Recent research highlights potential dangers associated with prolonged melatonin use for sleep issues. Chronic melatonin users were found to have almost double the risk of death and 3.5 times higher chance of hospitalization due to heart failure.
Study Findings Presented at AHA 2025
A preliminary study, shared at the American Heart Association's Scientific Sessions 2025, revealed that adults with chronic insomnia using melatonin for a year or more faced increased risks of developing heart failure and higher mortality compared to non-users. The session is held from November 7-10 in New Orleans, focusing on cardiovascular science and clinical advancements.
What Is Melatonin?
Melatonin is a hormone produced by the pineal gland that controls the sleep-wake cycle, naturally rising in darkness and falling during daylight. Synthetic melatonin, matching the natural hormone chemically, is commonly used to combat insomnia and jet lag.
Availability and Regulation
Melatonin supplements are sold over the counter in many countries, including the U.S. However, they are unregulated in the U.S., leading to significant variations in their purity and dosage.
"Adults with chronic insomnia who used melatonin for a year or longer were more likely to develop heart failure, be hospitalized for heart failure, and die from any cause than those who did not take the supplement."
Given these findings, experts recommend caution with long-term melatonin use despite its common reputation as a safe aid.
Summary: Extended melatonin use, widely considered safe, may increase heart failure risk and mortality, urging careful reconsideration of its prolonged use for sleep disorders.