Chronic Melatonin Use Linked to Increased Heart Failure Risk
Researchers have found evidence suggesting that taking melatonin for a year or longer is associated with a higher risk of heart failure. Melatonin, commonly used as a sleep aid, is still being studied for its long-term side effects amid growing widespread use.
Study Findings on Melatonin and Heart Health
A preliminary study examined medical records of individuals with chronic insomnia. Those prescribed melatonin for at least a year were more likely to develop heart failure and had a higher risk of death from any cause.
“These findings challenge the perception of melatonin as a benign chronic therapy and underscore the need for randomized trials to clarify its cardiovascular safety profile,” the researchers noted.
Melatonin: Natural Hormone and Synthetic Supplement
Melatonin is a hormone naturally produced by the body that helps regulate the sleep-wake cycle. Synthetic melatonin is approved in countries like the U.K. for treating insomnia in people over 55. In the U.S., melatonin is widely available over-the-counter as a dietary supplement.
Short-term use of melatonin, such as for jet lag relief, is generally considered safe for adults, though safety in children is less certain.
Study Limitations and Next Steps
The authors emphasize the study has important limitations but believe the findings warrant further research into melatonin's potential cardiovascular risks.
Author's summary: Long-term melatonin use may raise heart failure risk, highlighting the need for further clinical trials to assess its safety for chronic use.