Melatonin Linked to 90% Higher Risk of Heart Failure
New research suggests that the common sleep supplement melatonin might increase the risk of heart failure. However, experts emphasize the need for more studies to confirm these findings before drawing firm conclusions.
Study Overview
According to a press release from the American Heart Association, long-term use of melatonin was associated with a 90% higher likelihood of heart failure. The data also pointed to an increased risk of hospitalization or death from heart failure.
Details and Methodology
The research, which will be presented at the American Heart Association’s Scientific Sessions 2025, analyzed five years of medical records from over 130,000 adults diagnosed with insomnia. All participants had used melatonin for at least one year.
“Melatonin supplements may not be as harmless as commonly assumed. If our study is confirmed, this could affect how doctors counsel patients about sleep aids,” said Ekenedilichukwu Nnadi, M.D., lead author and chief resident in internal medicine at SUNY Downstate/Kings County Primary Care in Brooklyn, New York.
Expert Response
Despite the concerning findings, researchers caution against immediately stopping melatonin use. They stress that more robust, peer-reviewed studies are needed to understand whether melatonin directly causes heart-related issues or if other factors contribute to the increased risks.
Key Takeaway
- Melatonin was linked to 90% higher heart failure risk in long-term users.
- Experts call for further research before changing medical guidance.
- Data drawn from a large U.S. cohort over a five-year period.
Author’s summary: Preliminary findings connect prolonged melatonin use with elevated heart failure risk, yet experts advise caution until the data are confirmed through comprehensive studies.